A Comparative Study of Novel Super Disintegrating Agent, Guar gum to existing Super Disintegrating Agent, Sodium Starch Glycolate on Release Rate of Drug from Fast Dissolving Tablet
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چکیده
The aim of present study is to exist a novel super disintegrants in fast dissolving tablet. Guar gum is a natural substance and used in many pharmaceutical product and it can also used as a super disintegrating agent in fast dissolving tablet. The result is that it released the 99.21% drug in 15min as compared to Sodium Starch Glycolate (SSG), where only 97.51% drug was released. The onset of time was better for guar gum where, 84.79% of drug was released in 2min from F3 formulation as compared of F6 formulation where only 71.22% drug was released. The possible mechanism of disintegrating property was good swelling property of guar gum than SSG but when the concentration of guar gum was used above 8%, it created a problem on disintegration of tablet due to formation of gel layer around the tablet. All evaluating parameters were within range and no markedly difference was observed.
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